Conrad Waddington and the origin of epigenetics.
نویسنده
چکیده
Denis Noble discusses Conrad Waddington's classic paper, "The genetic assimilation of the bithorax phenotype", published in Evolution in 1956.
منابع مشابه
From Epigenesis to Epigenetics
One continuous thread in this volume is the name of Conrad H. Waddington (1905–1975), the developmental biologist known as the inventor of the term epigenetics. After some biographical notes on his life, this article explores the meaning of the Waddingtonian equation and the context wherein it was developed. This equation holds that epigenesis + genetics = epigenetics, and refers in retrospect ...
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In the process of cellular carcinogenesis, genetic and epigenetic mechanisms contribute to abnormal expression of genes. Conrad Waddington introduced the term ‘‘epigenetics’’ in 1942 (Goldberg, Allis et al. 2007) to describe heritable changes in gene expression that have no connection with changes in DNA sequence (Yoo and Jones 2006; Goldberg, Allis et al. 2007). The molecular basis of epigenet...
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The epigenetic landscape [2] is a concept representing embryonic development. It was proposed by Conrad Hal Waddington [3] to illustrate the various developmental pathways a cell might take toward differentiation [4]. The epigenetic landscape [2] integrates the connected concepts of competence [5], induction [6], and regulative abilities of the genes [7] into a single model designed to explain ...
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Introduced by Conrad Hal Waddington [3] in 1942, the concept of epigenetics [4] gave scientists a new paradigm of thought concerning embryonic development, and since then has been widely applied, for instance to inheritable diseases, molecular technologies, and indeed the human genome [5] as a whole. A genome [5] contains an embedded intricate coding template that provides a means of genetic ex...
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Conrad Hal Waddington?s Organisers and Genes [4], published in 1940, is a summary of available research and theoretical framework for many concepts related to tissue differentiation [5] in the developing embryo. The book is composed of two main conceptual sections. The first section explores the action and nature of the organizer [6], while the second section delves into genes [7] and their inf...
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ورودعنوان ژورنال:
- The Journal of experimental biology
دوره 218 Pt 6 شماره
صفحات -
تاریخ انتشار 2015